Dr. Chintan Vyas

Brief Profile

Dr Chintan Vyas is a Full-time Paediatric Haematology-Oncology, Immunodeficiency and BMT consultant with an experience of over 10 years. He has performed over 200 paediatric Bone Marrow transplants to date. He is also experienced in paediatric cellular therapies like Chimeric Antigen Receptor Therapy (CART) for paediatric leukaemia/lymphoma and activated NK cell therapy for solid tumours in children.

He completed MBBS from Gujarat and DNB (Paediatrics) from Sir Ganga Ram Hospital, New Delhi. He then pursued a Fellowship of National Board & Indian Academy of Paediatrics in Paediatric Haematology Oncology from Rajiv Gandhi Cancer Institute, New Delhi.

He further pursued 3 years of advanced fellowship in paediatric BMT and cellular therapy overseas from National University Hospital, Singapore, and gained excellence in T cell-depleted Haploidentical transplants, CART and activated NK cell therapy. Subsequently, he moved to London and worked as a Senior Clinical Fellow at Imperial College (St Mary’s Hospital) which is UK's apex centre for benign haematology transplants and gene therapy for haemoglobinopathies. He also worked at the prestigious Great Ormond Street Hospital which is a centre for excellence for performing the highest numbers of transplants for oncology immunodeficiency and metabolic diseases as well as CART and gene therapy.

Qualification

• MBBS, DNB (Paediatrics)
• FNB & FIAP (Paediatric Haematology-Oncology, Delhi, India)
• Fellowship in Paediatric Blood/Marrow Transplant (BMT) (National University Hospital, Singapore)
• Fellowship in Paediatric Haematology and BMT (Imperial College Healthcare NHS, London-UK)
• Fellowship in Paediatric Haematology, Oncology & BMT (Great Ormond Street Hospital NHS, London-UK)
• PDCR, ACPCR (India), CITI (Singapore), ECFMG (USA) certified

Fields of Expertise

• Paediatric Haematology-Oncology
• Paediatric Blood / Marrow / Cord Blood Transplant
• Advanced Cellular Therapy (CART / Activated NK cell therapy)
• Paediatric Immunodeficiency Diseases and EBV-related disorders
• Metabolic disorder and Congenital Syndromes
• Late effect & Survivorship

Awards & Recognition

• Best resident award (FNB) on the 20th Foundation day of RGCI (2016)
• 2nd prize - Poster presentation in Thalassemia International Federation (TIF) - Delhi 2012
• 2nd prize - National Neonatology Quiz (NARCHI) - Delhi 2012

Professional Memberships & Certifications

• Lifetime IAP-PHO Chapter, India (September 2019 - Till Date)
• SIOP
• EBMT

Publications

• Vyas C., Jain S., and Kapoor G. (2018). Therapy Related AML/MDS following treatment for childhood cancer: Experience from a Tertiary Care Centre in North India. Indian Journal of Hematology & Blood Transfusion: 34(1), 78–82.
• Vyas C., Jain S., Kapoor G et al, (2018). Experience with generic pegylated L-asparaginase in children with acute lymphoblastic leukaemia and monitoring of serum asparaginase activity. Pediatric Hematology and Oncology, 35(5-6), 331–340.
• Impact of memory T-cell doses infused with T-cell depleted haploidentical stem cell grafts on transplant outcomes. EBMT (2020) (Poh Lin Tan, Chintan Vyas, Mariflor Villegas et al)
• Treosulfan-based conditioning in paediatric T-cell depleted haploidentical stem cell transplants: a single centre experience. EBMT (2020) (Frances Yeap, Chintan Vyas, Poh Lin Tan, Mariflor Villegas et al)
• Hypersensitivity and silent inactivation with generic pegylated L-asparaginase in children with acute lymphoblastic leukaemia. Paediatric Blood Cancer.66 (Suppl. 4):e27989 (2019) (Gauri Kapoor, Sandeep Jain, Chintan Vyas)
• Allogeneic stem cell transplantation in children: single centre experience from North India. Paediatric Blood Cancer.65:e27455 (2018) (Chintan Vyas, Faizuddin Ansari, Anjali Pandit et al)
• Leflunomide therapy for BK virus-associated haemorrhagic cystitis in paediatric HSCT recipients, a single centre experience from India. St Jude-VIVA Forum, Singapore (2018) (Chintan Vyas, Anjali Pandit, Faizuddin Ansari, Vikas Dua)
• Oral valganciclovir used as pre-emptive therapy for cytomegalovirus reactivation in paediatric allogeneic stem cell transplant patients: a single centre experience from North India. Pediatric Hematology Oncology 3; S7eS65 (2018) (Chintan Vyas, Anjali Pandit et al)
• Varied presentation of human herpes virus infection in children following allogeneic HSCT. Paediatric Haematology Oncology Journal 3; S7eS65 (2018) (Anjali Pandit, Chintan Vyas, Faizuddin Ansari, Vikas Dua)
• Oral presentations: (1) Therapy-related AML/MDS in children- SIOP ASIA, Bangkok, (2017); (2) Efficacy and safety profile of deferasirox at various doses on transfusional hemosiderosis in β-thalassemia major”, PHOCON- Chennai (2014)
• Efficacy and side effect profile of deferasirox on cardiac iron overload EGM Iron Summit, New Delhi (2013) (Chintan Vyas, et al)
• The efficacy and side effect profile of deferasirox at various doses in iron overloaded patients with β thalassemia major. TIF World Congress, Abu Dhabi, October. (2013) (Chintan Vyas, Dinesh Kaul, Virender Khanna)
• Walking two worlds’ psychological assessment and support to children and young adult cancer patients in New Delhi. 35th meeting of ESMO, Milan, Italy, October. (2010) (Prakash Chitalkar, Jagrit Singh, Chintan Vyas et al)

RESEARCH PROJECTS

• Audit:- Availability of infection markers test results at the time of stem cell harvest- St Mary’s Hospital, Imperial College London (Chintan Vyas, José De La Fuente, Gassas Adam, Leena Karnik)
• Gastrointestinal graft-versus-host disease in paediatric allogeneic hematopoietic stem cell transplant recipients (Ethics approved study) PI: Tan Poh Lin; Co-I: Chintan Vyas, Venkatesh Karthik
• 5-year experience of T cell-depleted haploidentical stem cell transplants in children at NUH, presented in Singapore-Annual BMT Meeting (October 2019) (Chintan Vyas, M Villegas, Frances Yeap, Tan Poh Lin)
• Immune reconstitution following T-cell depleted haploidentical transplants in children. (Chintan Vyas, Dr Tan Poh Lin)
• Hydroxyurea treatment in patients with β thalassemia major with Xmn-1 polymorphism (Chintan Vyas, V. K. Khanna)

Key Procedures Performed

• Bone marrow and peripheral blood stem cell harvest, incudes advanced T cell depletion techniques like CD4 RA depleted and RO+ transplants
• Cord Blood Stem Cell Transplants
• Chimeric Antigen Receptor Therapy Infusion and management of complications including autologous, lymphocyte harvest
• Activated NK Cell therapies (Donor-derived and also Autologous)
• Gene therapies
• Advanced immunotherapy for paediatric solid tumours as well as liquid malignancies

Languages Spoken

English, Hindi, Gujarati