Bone marrow biopsy and aspiration can show whether your bone marrow is healthy and making normal amounts of blood cells.

Why it's done

Bone marrow biopsy and bone marrow aspiration offer detailed information about the condition of your bone marrow and blood cells such as Lymphoma/ Leukemia

Your doctor may perform a bone marrow exam to:

Diagnose a disease or condition involving the bone marrow or blood cells
Determine the stage or progression of a disease and to monitor the treatment of a disease
Investigate a fever of unknown origin
Anemia
Cancers that have spread from another area, such as breast,lung etc into the bone marrow
Hemochromatosis etc.

Risks

Bone marrow exams are generally safe procedures. There are no long term side effects. Acute complications are rare but can include:

Excessive bleeding, particularly in people with low numbers of a certain type of blood cell (platelets)
Infection, especially in people with weakened immune systems
Long-lasting discomfort (pain or tenderness) at the biopsy site.

How you prepare

Bone marrow exams are often performed on an outpatient basis. Special preparation usually isn't needed.
Tell your doctor about medications and supplements you take prior to the procedure. Certain medications and supplements may increase your risk of bleeding after a bone marrow biopsy and aspiration eg, Aspirin, Heparin etc.
Tell your doctor if you're nervous about your procedure. Discuss your worries about the exam with your doctor. In some cases, your doctor may give you a sedative medication before your exam, in addition to a numbing agent (local anesthesia) at the site where the needle is inserted.

What you can expect

A bone marrow biopsy and aspiration can be done in a hospital, clinic or doctor's office.

The bone marrow exam typically takes about 10 minutes. Extra time is needed for preparation and post-procedure care, especially if you receive intravenous (IV) sedation. The total time for the procedure is about 30 minutes.

Before the procedure

Your blood pressure and heart rate will be checked, and you'll be given some form of local anesthesia to keep you comfortable.
Most people need only local anesthesia, as bone marrow aspiration, in particular, can cause brief, but sharp, pain. You'll be fully awake during the procedure, but the aspiration and biopsy site will be numbed to reduce pain.
If you feel anxious about pain, you may be given an IV medication so that you're either completely or partially sedated during the bone marrow exam.

During the procedure

The area where the doctor will insert the biopsy needle is marked and cleaned. The bone marrow fluid (aspirate) and tissue sample (biopsy) are usually collected from the top ridge of the back of a hipbone (posterior iliac crest). Sometimes, the front of the hip may be used.
Bone marrow aspiration is occasionally collected from the lower leg bone in children under the age of 12 to 18 months.
You'll be asked to lie on your abdomen or side, and your body will be draped with cloth so that only the exam site is showing.

Bone marrow aspiration

The bone marrow aspiration is usually done first. The doctor makes a small incision, then inserts a hollow needle through the bone and into the bone marrow.
Using a syringe attached to the needle, the doctor withdraws a sample of the liquid portion of the bone marrow. You may feel a brief sharp pain or stinging. The aspiration takes only a few minutes. Several samples may be taken.
The health care team checks the sample to make sure it's adequate. Rarely, fluid can't be withdrawn and the needle is moved for another attempt.

Bone marrow biopsy

Your doctor uses a larger needle to withdraw a sample of solid bone marrow tissue. The biopsy needle is specially designed to collect a core (cylindrical sample) of bone marrow.

After the procedure

Pressure will be applied to the area where the needle was inserted to stop the bleeding. Then a bandage will be placed on the site.
If you had local anesthesia, you'll be asked to lie on your back for 10 to 15 minutes and apply pressure to the biopsy site. You can then leave and go about your day, returning to normal activity as soon as you feel up to it.
If you had IV sedation, you'll be taken to a recovery area. Plan to have someone drive you home, and take it easy for 24 hours.
You may feel some tenderness for a week or more after your bone marrow exam. Ask your doctor about taking a pain reliever, such as acetaminophen, if needed.

Site care

Wear the bandage and keep it dry for 24 hours. Don't shower, bathe, swim or use a hot tub. After 24 hours you can get the aspiration and biopsy area wet.

Contact your doctor if you have:

Bleeding that soaks through the bandage or doesn't stop with direct pressure
A persistent fever
Worsening pain or discomfort
Swelling at the procedure site
Increasing redness or drainage at the procedure site
To help minimize bleeding and discomfort, avoid rigorous activity or exercise for a day or two.