Alzheimer’s disease is a neurodegenerative disorder & the most common cause of dementia. There is a continuous decline in thinking, behavioural & social skill leading to a decrease in functioning independently. This disease is named after Dr Alois Alzheimerin 1906. This condition usually affects aged 65 yrs or over & 10% of cases occurring in younger people. Staging – Mild, Preclinical, Moderate & Severe.
The common symptoms of Alzheimer’s are –
Moderate Stage – Increasing damage of the areas of the brain leading to
Latex/ Severe Stage
Preclinical Alzheimer’s disease – The patient presents with mild cognitive impairment (MCI), the affected regions begin to atrophy these brain changes occurs decades before any signs/symptoms appear.
Pathology /Whats happens inside the brain – Certain area of the brain which is essential for memory, language, executive functions and getting atrophied slowly, start in entorhinal cortex – near formation hippocampus (essential to short term & long term memories). Then progresses to affect various regions off cerebral cortex, leading to others dysfunction. Senile plaques (SP) & Neurofibrillary triangles (NFT) are the hallmark of the disease.
How to diagnosis
Treatment It’s a progressive disorder. Only symptomatic treatment is available, no drug to half the progress of the disease. Research is going on & there are some experimental treatments.
The patient can get benefit from
Hospitalisation is essential for patients in a severe stage with certain other medical condition.